Development of advanced macrosphelides: potent anticancer agents.
نویسنده
چکیده
Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography preparation. In addition, advances in their apoptosis-inducing activities are also included.
منابع مشابه
Synthetic advances in macrosphelides: natural anticancer agents.
Total synthesis of macrosphelides is summarized. Synthetic approaches contain the preparation of key fragments and the final ring-closure reaction for unique 16- or 15-membered macrolactone skeletons.
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ورودعنوان ژورنال:
- Molecules
دوره 20 3 شماره
صفحات -
تاریخ انتشار 2015